Jordan Klaiman

Education

Ph.D. Candidate, Integrative Biology, University of Guelph

B.Sc. Hons. Biology, University of Western Ontario

Research

Rainbow trout (Oncorhynchus mykiss) are ectotherms, therefore their body temperature is determined by environmental temperatures. Despite being exposed to a wide range of temperatures (~4ºC to ~20ºC) over the year they remain active. Their heart, along with the rest of their organs must, therefore, remain functional in this temperature range. At cold temperatures, there are many challenges that the vertebrate heart faces including: increased viscosity of the blood, impaired actomyosin ATPase activity and decreased sensitivity of the contractile elements to Ca²⁺. These challenges contribute to an overall decrease in cardiac output which results in reduced activity of the organism. To compensate for these temperature effects, so as to remain functional, it is expected that there will be significant changes to the proteins responsible for muscle contraction and regulation in the trout heart during cold acclimation. Therefore, there are two objectives to my research project: (1) to characterize the cardiac proteome of cold acclimated rainbow trout and (2) to correlated protein changes with changes in actomyosin ATPase activity (a measure of cardiac activity).

Awards

NSERC - CGSD (2010-2013)

OGS - (2009/2010)

OGS - Science and Technology (2009)

Publications

Sarah L. Alderman*, Jordan M. Klaiman*, Courtney A. Deck and Todd E. Gillis (In Press) Effect of cold acclimation on troponin I isoform expression in striated muscle of rainbow trout. American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology

Klaiman JM, Fenna AJ, Shiels HA, Macri J, Gillis TE. (2011) Cardiac Remodeling in Fish: Strategies to Maintain Heart Function during Temperature Change. PLoS ONE 6(9): e24464. doi:10.1371/journal.pone.0024464

Todd E. Gillis and Jordan M. Klaiman. (2011) The influence of PKA treatment on the Ca²⁺ activation of force generation by trout cardiac muscle. Journal of Experimental Biology 214, 1989-1996 

Kelly P. Kirkpatrick, Andrew S. Robertson, Jordan M. Klaiman and Todd E. Gillis. (2011) The Influence of trout cardiac troponin I and PKA phosphorylation on the calcium affinity of the troponin complex. Journal of Experimental Biology 214, 1981-1988

Jordan M. Klaiman, Edwin R. Price and Christopher G. Guglielmo. (2009) Fatty acid composition of pectoralis muscle membrane, intramuscular fat stores and adipose tissue of migrant and wintering white-throated sparrows (Zonotrichia albicollis). Journal of Experimental Biolgoy 212, 3865-3872

Brown, J. C. L., Mcclelland, G. B., Faure, P. A., Klaiman, J. M. & Staples, J. F. (2009) Examining the mechanisms responsible for lower ros release rates in liver mitochondria from the long-lived house sparrow (passer domesticus) and big brown bat (eptesicus fuscus) compared to the short-lived mouse (mus musculus). Mechanisms of Ageing and Development 130, 467-476.

E-Mail: jklaiman@uoguelph.ca

Mailing Address:

Dept. of Integrative Biology
488 Gordon St.
University of Guelph
Guelph, Ontario N1G-2W1
Canada
1-519-824-4120 x. 56963